Hypertensive Effect of Downregulation of the Opioid System in Mouse Model of Different Activity of the Endogenous Opioid System

The opioid system is well-known for its role in modulating nociception and addiction development. However, there are premises that the endogenous may also affect blood pressure. main goal of present study was to determine impact different activity pharmacological blockade on Moreover, we examined vascular function hyper- hypoactive states modification. In our study, used two mouse lines which divergently bred high (HA) low (LA) swim stress-induced analgesia. obtained results indicated individuals with have higher basal pressure compared those a hyperactive system. Additionally, naloxone administration only resulted elevation HA mice. We showed contributes impaired relaxation independent endothelium, corresponded decreased guanylyl cyclase levels aorta. Together, these data suggest LA mice result disturbed mechanisms smooth muscle cells. believe novel mechanism involves regulation will be promising target further studies hypertension